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APP/PS1 (APP Swedish + PS1 deltaE9) : historical model, useful for longitudinal studies (12-18 months)

It is important to note the regions of the brain that are more susceptible to the changes in BBB integrity as regions like the hippocampus and amygdala are heavily affected in neurodegenerative disease as they are vital for long-term memory and processing emotions and behavior

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Hypoxia also induces cellular adaptations which can hinder the efficacy of chemotherapy, such as reduced cellular uptake of drugs due to increased cellular acidity and drug efflux pump expression [82], whilst some chemotherapeutic agents require oxygen in order to facilitate their cytotoxicity [24]