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There is also a specific biological reason the systemic route attracted attention

295 In all inhibitors of WNT signalling, niclosamide is FDA-approved drug and was used to treat taeniasis, showing inhibiting effect on tumours proliferation, stemness and metastasis by causing FZD1 receptor internalization and decreasing the protein level of DVL2, as well as targeting LRP6

Solution: Set realistic expectations aligned with the timelines described earlier

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