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The imbalance of gut microbiota, such as the decrease of Bifidobacterium and Lactobacillus, and the increase of pathogenic bacteria, can stimulate the secretion of pro-inflammatory cytokines by increasing the intestinal epithelial permeability, while Lactobacillus and Bifidobacterium can down-regulate the secretion of pro-inflammatory cytokines

Testing for MTHFR variants is done for several purposes: Homocysteine Levels and Cardiovascular Risk : Variants in the MTHFR gene can lead to elevated homocysteine levels, a known risk factor for cardiovascular diseases such as heart attack and stroke

Therefore, the objective of this review is to debate about non-medical approaches to increase HDL-c, such as nutritional and training strategies, and to discuss the central mechanisms involved in the modulation of lipid profile during exercise, as well as that can be controlled by physical trainers or sports specialists in attempt to maximize the benefits promoted by exercise

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