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Obeid et al

There are two alpha-2-adrenergic agonists that have some evidence as pain relievers: tizanidine (Zanaflex) and clonidine (Catapres)

It is not approved for human or veterinary therapeutic use, self-administration, or any clinical application

Cellular nitric oxide production in vascular endothelial cells was detected by the emitted fluorescence from DAF-FM DA probe upon the interaction with nitric oxide