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doi: 10.3389/frdem.2026.1745504 Received 13 November 2025 Revised 21 December 2025 Accepted 16 January 2026 Published 04 February 2026 Volume 5 - 2026 Edited by Matea Nikolac Perkovi, Rudjer Boskovic Institute, Croatia Reviewed by Xifeng Wang, First Affiliated Hospital of Nanchang University, China Paolo Abondio, IRCCS Institute of Neurological Sciences of Bologna (ISNB), Italy Updates Copyright 2026 Perezcano and Prez-Coria

For patients who cannot absorb nutrition through the gut, IV nutrition support is lifesaving

Total Hcy and total cysteine levels (total Cys: free and protein-bound cysteine) in the serum were measured using an HPLC method [27]

Sudden or Severe Pain in the Injected Joint : When patients feel severe or sudden pain in the treatment area, this may be a sign of a severe side effect