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When Phase 1 activity exceeds Phase 2 capacity, reactive intermediate metabolites may accumulate faster than they can be neutralized

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2 Myelination and remyelination in axonal regeneration To attain proper functional and structural integration, tNs must recapitulate both cell-intrinsic and cell-extrinsic aspects of the endogenous circuits, which requires tNs to interact with the surrounding endogenous neurons and glial cells