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This fundamental metabolic failure is a primary driver of post-exertional malaise (PEM), the hallmark symptom of ME/CFS where even minor exertion triggers a severe exacerbation of systemic symptoms

Unvalidated hypotheses include the stability of NTF-mediated mitochondrial regulation in the chronic -syn pathological environment, the universality of cell subtype specificity in patients, and the direct causal relationship between structural optimization and functional improvement, all of which lack sufficient data support

Furthermore, Pycnogenol supplementation significantly reduced pro-inflammatory mediators (leukotrienes) in the blood of patients, as compared to both baseline values and placebo

Purity: 98%