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doi:10.1016/j.ekir.2019.05.001 89 Ostermann M, Summers J, Lei K, et al

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conducted interventional human studies, including dose-escalation studies, to assess whether combined treatment with UA 1000 mg (infused intravenously in 90 min during the infusion of alteplase) and alteplase improved functional outcomes at 90 days in patients with acute stroke [151]