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Quinolinic acid, a kynurenine/tryptophan pathway metabolite, associates with impaired cognitive test performance in systemic lupus erythematosus

The failure of broader or less specific agents, therefore, reinforces the central theme that therapeutic success in MIRI demands a highly targeted approach that addresses the specific downstream consequences of the initial oxidative insult

Relative gene expression was calculated using the comparative Ct method (2 Ct ) 41

Expert Opin Drug Metab Toxicol 5:10231038 Nicholson JK, Lindon JC, Holmes E (1999) Metabonomics: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data