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doi: 10.1111/j.1600-0897.2010.00852.x 95 GlebezdinaNSNekrasovaIVOlinaAASadykovaGKKuklinaEM

[10] IGF-1 levels are correlated with insulin sensitivity, where lower levels of IGF-1 would appear to coincide with a decrease in in insulin sensitivity

Mitochondrial dysfunction and oxidative stress play significant roles in neurodegenerative diseases, and both generate high levels of reactive oxygen species (ROS), which are harmful to all cellular macromolecules