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Nanoparticle-Based Enzyme Replacement Therapy for Neurological Disorders Enzyme deficiency disorders are a diverse group of diseases caused by deficiency or malfunction of specific enzymes, which may lead to the accumulation of toxic substances or disruption of key metabolic pathways, thus ultimately resulting in systemic damage and dysfunction

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Accumulated hepatic lipids, formed either by DNL or from free fatty acids, have been linked to the onset of hepatic insulin resistance

Most of the hepatocytes restored the normal appearance of the cytoplasm and nuclei