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16, 21 Therefore, we have undertaken extensive studies to determine the potential for BSO to enhance the anti-myeloma activity of L-PAM at clinically achievable doses using in vitro (cell lines and fresh MM explants) and in vivo MM xenografts to determine if BSO+L-PAM warrants clinical trials in MM

During pregnancy and lactation, the fetus and infant are entirely reliant on maternal iodine intake for thyroid hormone synthesis

Those include free radicals (molecules containing one or more free electrons), such as superoxide (O 2 ), hydroxyl (OH ), peroxyl (ROO ), and alkoxyl (RO ), and nonradicals molecules (with paired electrons) such as singlet oxygen ( 1 O 2 ), hydrogen peroxide (H 2 O 2 ), organic peroxides (ROOH, hydroperoxides), and ozone (O 3 ), among others (Fig