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Moreover, studies have found that compared to healthy controls, PCOS patients exhibit downregulated expression of genes including ferritin heavy chain 1 (FTH1), HAMP, GPX4, A2M, and HP, and upregulated expression of nuclear receptor coactivator 4 (NCOA4), along with enhancement in lipid peroxidation, serum ferritin, and total protein content, and inhibition in peroxidase activity (140)