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Ethical approval The study was approved by the Institutional Review Board of Bhumibol Adulyadej Hospital and was registered in the Thai Clinical Trials Registry (TCTR) with the registration number TCTR20221105001

The right hemisphere of the brain was snap-frozen in liquid nitrogen (LN 2 ) and stored at 80 C until subsequent biochemical analysis

Western blotting S2 cell pellets were lysed on ice for 30 min in three times packed volume RIPA buffer (50 mM Tris, pH = 8, 150 mM NaCl, 1% Nonidet P-40, 0.5% sodium deoxycholate, 0.1% SDS, Pierce Protease Inhibitor Tablet [A32963