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Melanin synthesis in melanocyte or melanoma cells is mainly regulated by the MC1R/MITF/tyrosinase-signaling pathway. Journal of Advanced Pharmaceutical Technology & Research, 2020 Link to study When melanocytes downregulate this pathwayeither due to aging, oxidative stress, or genetic predispositionthe result is melanin depletion and visible gray or white hair , clinically referred to as canities

NAC and Resveratrol N-acetylcysteine (NAC) and resveratrol are both antioxidants that can decrease DNA damage in the breast tissue and reduce the malignant transformation of cultured breast epithelial cells

LC-MS metabolomic analysis For the LC separation, column A was the Sequant Zic-Hilic (150 mm 4.6 mm, internal diameter (i.d.) 5 m) with a guard column (20 mm 2.1 mm i.d