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Its limitation is the inability to reverse effects once tolerance is established, making it potentially ineffective in monocytes that have already experienced inflammatory activation

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2 Review methodology The review and research articles were retrieved using relevant keywords (involving curcumin, neurodegenerative diseases, Alzheimers disease, Parkinsons disease, Huntingtons disease, amyotrophic lateral sclerosis, toxic proteins, tau protein, -Amyloid, alpha synuclein, brain, neuron, apoptosis, metal homeostasis, chelation, ferroptosis, cuproptosis, mitochondria damage, inflammation, oxidative stress, pharmacological effects, neuroprotection, antioxidation/antioxidant, anti-inflammation/anti-inflammatory, mechanism, signal pathway, bioavailability, clinical trial, and so on) from the website and databases including ScienceDirect, Google Scholar, Web of Science, ResearchGate, and PubMed