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For instance, phosphorylated forms of thiamin, including thiamin diphosphate (TDP) and thiamin pyrophosphate (TPP), are required cofactors for enzymes of glycolysis, the citric acid cycle, and the pentose phosphate pathway (22)

This was noted to raise serum LPS levels and F/B ratio, which is a primary indicator of microbial imbalance that happens with the decrease of estrogen

Wilson JR, Tetreault LA, Kwon BK, Arnold PM, Mroz TE, Shaffrey C, et al