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Subtle improvements in sleep quality Reduced morning stiffness Slightly improved activity tolerance Possible temporary sensitivity at injury sites Gradual reduction in baseline discomfort Progressive Phase (Weeks 4 to 8) The middle phase of treatment typically brings more noticeable improvements

however, ABHD5 lacks an active serine found in other ABHD family members (33), in which possibilities might include promoting access to the TAG core through remodeling of the phospholipid monolayer, or removal of reaction products

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doi: 10.1038/nrd2974