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Elevated beta-glucuronidase levels often result in higher levels of proliferative estrogen metabolites such as 4-OH Estrone and 16A-OH Estrone and negatively skew important ratios such as 2-OH (E1 + E2)/16a-OH E1, which is believed to be an independent risk factor for breast cancer

Whole-cell current clamp recordings were made with a headstage (CV-7B) connected to a computer-controlled amplifier (MultiClamp 700B, Axon Instruments), digitized through a Digidata 1440A Analog/digital converter and acquired at a sampling rate of 10 kHz

10.1007/s11033-022-07270-y 48 Gonzalez de MejiaE.Ramirez-MaresM

According to the specific redox state of the patient's uterine fibroids, intervention strategies of antioxidant or pro-oxidant therapy can be precisely selected, thereby achieving truly targeted therapy