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One randomized, double-blind, placebo-controlled trial published in Sleep found that nightly supplementation with three milligrams of melatonin for three weeks in hypertensive patients on beta-blockers significantly improved sleep by increasing total sleep time (by about 36 minutes), improving sleep efficiency and reducing sleep onset latency (by about 14 minutes) compared to placebo

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Patient stratification using predictive biomarkers will be crucial for identifying those most likely to benefit from HDAC-based autophagy modulation