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Description

Recruitment and assembly of endosomal sorting complex required for transport (ESCRT) IIII rapidly counteracts membrane damage, but it is unclear how ESCRT-I recognizes defective lysosomal membranes

Kidney health There are several mechanisms by which this may work

doi: 10.1152/ajpendo.00629.2013

After stringent washing, samples were separated by SDS-PAGE and biotin-CCW16-RNF4 conjugates were detected using streptavidin linked to a fluorophore (Fig