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Full therapeutic benefit typically becomes evident within three to six months, with many patients experiencing sustained pain relief that persists long after the treatment course ends

Owing to the peptide's potential to "fine tune" the immune cells, they may not reject transplanted bodies, potentially leading to successful transplantation experiments in laboratory models

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Here, we investigated the analgesic effect of nicotine and indicated that nicotine may alleviate the peripheral nerve regeneration process and pain through regulating PTEN and the downstream inflammation-related pathway