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This early phase is capable of inducing a short-term rise in NF-B and Bax even when downstream oxidative markers subsequently improve

Myocardial membrane cholesterol: effects of ischaemia

Furthermore, metformin regulates fatty acid (FA) synthesis through the AMPK/SREBP-1 pathway, thereby reducing the likelihood of malignant transformation in cancer cells (Zhou et al., 2024

The latter include antioxidant enzymes such as superoxide dismutase 1 (SOD1), catalase (CAT), glutathione peroxidase (GP), GST, NAD(P)H quinone oxidoreductase 1 (NQO1), and others