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MSCs exert their therapeutic effects on PNI possibly through their dual functions, multipotent differentiation capacity into neural type of cells and their paracrine secretion of an array of bioactive factors with multiple trophic effects on both neural and nonneural cells [13], whereby the potent immunomodulatory effects of MSCs on immune cells, particularly macrophages, may constitute one of the major mechanisms by which MSCs exert their therapeutic effects on PNI [14]

Time course of the level of MK4 in plasma, kidney and liver after intraperitoneal bolus injection of MK4 (200 mg/kg) to Gpx4 fl/fl mice

To address this issue, inhibitors targeting mutant BRAF and MEK, a downstream target of BRAF, have been developed as first-line treatments for melanoma patients with BRAF mutations

A variant of lymphocytic thyroiditis