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Active aerobic glycolysis produces lactate as an end product which is expelled to ECM by Monocarboxylate transporter 4 (MCT4) forming an acidic microenvironment that is necessary for tumor growth, metastasis, immunosuppression, vascularization, and therapeutic resistance [290]

Examples of non-enzymatic antioxidants include vitamins C and E, plant polyphenols, carotenoids, and glutathione (Shahidi and Zhong 2010

The discovery of novel diagnostic biomarkers such as cathepsin S , B-cell-activating factor , and myxovirus resistance protein A can help patients receive earlier diagnoses and prompt treatment