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doi: 10.3390/ijms150712895 23 HorieIAbiruNNagayamaYKuriyaGSaitohOIchikawaTet al

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moderate evidence supports the use of capsaicin cream or a lidocaine patch as a second-line agent

The biofilm matrix acts as a physical barrier to block antifungal penetration, and the sessile fungal cells exhibit metabolic dormancy and upregulated expression of drug efflux pumps and target-modifying genes, and the presence of drug-resistant cells are some of the main factors leading to immune evasion and weakened response to available drugs (Sahoo et al., 2025)