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In senescent cells, cytosolic chromatin fragments and mtDNA, released from mitochondria, act as damage-associated molecular patterns (DAMPs), that are recognized by cGAS (Victorelli et al., 2023

It is reported that Leishmania and Toxoplasma gondii can suppress the production of inflammatory cytokines, chemokines, and the expression of costimulatory molecules in M via interference with MAPK, NFB, STAT3, or activation of STAT6-PPAR/ pathways, thus promoting M to differentiate towards anti-inflammatory M2 phenotype