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doi: 10.1016/s2214-109x(13)70145-1 217 ZarubinaAVNeelyDCClarkMEHuisinghCESamuelsBCZhangYet al

ThTP is another thiamine derivative found in many cell types, including bacteria, but it is generally of minor abundance compared to ThDP

It is thus necessary to develop a non-folic acid homocysteine-lowering approach for hyperlipidemia, because the lack of benefit of homocysteine-lowering therapy suggests that folic acid-based treatment that is still most widely used may increase the cardiovascular risk that has already been elevated in the hyperlipidemic setting