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For those with active lifestyles, like athletes or individuals with high-stress jobs, weekly or bi-weekly sessions may be recommended to help with recovery, hydration, and energy levels

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130 PMC (2026a)

Key Mechanisms Delta-wave sleep promotion Cortisol modulation LH release modulation Somatostatin interaction Endorphin system modulation Primary Research Areas Sleep architecture Insomnia Stress-related sleep disturbance Circadian regulation Pain modulation Key Research Findings Promoted delta-wave sleep in EEG studies without next-day sedation Normalized disturbed sleep patterns in chronic insomnia models Reduced ACTH and cortisol levels during stress in animal models Research Overview A nonapeptide first isolated in 1974 from the cerebral venous blood of rabbits during induced slow-wave sleep