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For instance, short-term fasting or stimulation of the peroxisome proliferator-activated receptor (PPAR) family, hepatocyte nuclear factor 4 (HNF4) or PR-domain containing 16 (PRDM16) ultimately activate the FAs -oxidation (FAO) program or genes, thereby increasing the number of ISCs and enhancing their self-renewal potentiality 11,12,13,14