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Under physiological conditions, ferritin-bound or excess Fe 2+ is delivered to lysosomes via NCOA4-mediated ferritinophagy or through direct uptake by transporters such as ZIP8, ZIP14, and DMT1

In a specific case, after being placed in a portable hyperbaric chamber and having the oxygen delivery rate reduced from 3 L/min to 0.5 L/min for ~8 h, the patient experienced some relief of symptoms but ultimately required helicopter evacuation to the nearest hospital for further care

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In detail, anesthesia was induced by intraperitoneal administration of chloral hydrate (400 mg/kg body weight)