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Comment: Some commenters agreed with our proposal to recognize the signed and dated order for only the initial certification and that the existing signature requirements should be kept for certifications when the patient does not have an order or referral and for all recertifications irrespective of a whether the patient has a referral

Research suggests elevated MMP-1 (a collagen-degrading enzyme) may contribute

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It contains an advanced peptide complex that helps stimulate the production of collagen and elastin , which promotes skin firmness and reduces the appearance of fine lines and wrinkles