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This efficacy differential highlights an important trade-off in the oral GLP-1 space: orforglipron offers the convenience of oral administration and freedom from injection but, based on current data, produces somewhat less weight loss than the most potent injectable multi-receptor agonists

[DOI] [PubMed] [Google Scholar] 78.Taschler U, Schreiber R, Chitraju C, Grabner GF, Romauch M, Wolinski H, et al