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To demonstrate the advantages of bivalent target binding through the full IgG format for enhancing avidity and selectivity, compared to most clinically approved bispecific T cell engagers that rely on monovalent binding, we introduced mutations (H91A and Y92A) in the complementarity-determining regions of Her2 to generate Her2 variants with reduced target binding affinity

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GHK-Cu is a naturally occurring peptide found in human plasma, saliva, and urine

Peptides act as biological messengers, prompting the skin to produce collagen, elastin, and other proteins essential for a firm, smooth complexion