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Although discredited at that time, from the discovery of the first ribosomopathy DiamondBlackfan Anemia in 1999, the ribosome has transitioned from a passive molecular machine to a dynamic macromolecular machine [89] [90] .Ribosomes are compositionally heterogeneous between species and even within the same cell, as evidenced by the existence of cytoplasmic and mitochondria ribosomes within the same eukaryotic cells