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Diagnostic confirmation is made by the increase of short-, medium-, and long-chain acyl-carnitines on acylcarnitine analysis and characteristic urinary organic acid pattern comprising elevated levels of glutaric, ethylmalonic, 3-hydroxyisovaleric, 2-hydroxyglutaric, 5-hydroxyhexanoic, and relevant ketonuria, particularly glycine conjugates of C4 and C5 acids [137,138]

For most participants, symptoms resolved or became manageable within the first two to three weeks at each dose level

Br Med J (Clin Res) 284(6320):927928 Coffin PO, Sullivan SD (2013) Cost-effectiveness of distributing naloxone to heroin users for lay overdose reversal

Medium dogs 25 to 50 lbs, 2 mL daily