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(3) Alkaloids: Nelumbine, a bioactive alkaloid isolated from lotus leaf, exhibits strong antioxidant properties and targets the suppression of folate-induced ferroptosis-related renal pathological changes by regulating the levels of GPX4, SLC7A11, and FSP1

Ligand discovery for orphan peptides typically begins with a structurally constrained pharmacophore that can be mapped against candidate receptor binding pockets

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