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The authors also point out that in some rare genetic disorders of B12 metabolism, the active forms may be required, and that smokers, who tend to have an excess of thiocyanate in their blood, may benefit from a taking a form other than cyano-B12

This is especially important for patients who have any GI-related problems: reflux/heartburn, SIBO/SIFO, chronic constipation, leaky gut, patients who are on acid blockers, etc