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In some circumstances, trigeminal neuralgia can worsen over time, with longer and more frequent pain episodes

Increased expression of both CD55 and CD59 has been seen on MM cells during disease progression on daratumumab treatment, indicating that overexpression of complement inhibitors is likely tied to daratumumab resistance [35]

It's crucial to note that Tesofensine can cause an increase in heart rate and blood pressure, although these changes have generally been modest in clinical trials