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Kuroda J, Kimura S, Andreeff M , Ashihara E, Kamitsuji Y, Yokota A, Kawata E, Takeuchi M, Tanaka R, Murotani Y, Matsumoto Y, Tanaka H, Strasser A, Taniwaki M, Maekawa T

The questions the EPIC trial raised were whether daily oral administration of the drug pimobendan to MVD-affected dogs before they reached heart failure (CHF), (a) was safe and well tolerated, and (b) would prolong the length of time MVD-affected dogs lived before reaching CHF

12 A systematic review (N = 18 trials) evaluated the effects of long-term inhaled antibiotic therapy on lung function and exacerbation frequency in CF individuals