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Ideally, the animal model should express the same kind of virus receptors, and the receptors should be distributed in similar anatomical locations to those of humans, such that they get infection via a similar route of transmission as do human beings (168)

In the brain, glutamate can be directly synthesized de novo by astrocytes or indirectly produced from glucose molecules through the actions of pyruvate dehydrogenase and astrocyte-specific enzyme pyruvate carboxylase (Krzyanowska Pomierny et al., 2014

This may cause an allergic reaction, which can cause a rash, itchy skin, watery and/or red eyes, swelling of the face and throat, diarrhea, nausea, and vomiting

doi: 10.1021/jf405820v