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GSH ethyl ester (10 mM) decreases reactive oxygen species (ROS) levels and TNF-alpha-induced IL-8 secretion in IB3-1 cells

As we go up the evolutionary ladder to the extracellular Kinetoplastidae members like Trypanosoma and Leishmania , it is seen that they have a well-developed TS pathway as well as enzymes involved in glutathione metabolism 13

As such, one possible interpretation of these findings is that GSHee does not entirely blunt the processes by which fentanyl suppresses inspiratory drive (Vt/Ti) it does have more pronounced effects on the processes by which fentanyl suppresses PIF