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Bone structure and natural healing process Hierarchical organization: Bone consists of mineral phase (hydroxyapatite calcium phosphate crystals providing hardness), organic phase (type I collagen fibers providing flexibility), and cellular components (osteoblasts building bone, osteoclasts resorbing bone, osteocytes sensing mechanical stress)

Interestingly, the increased citrate utilization by the gut commensal and opportunistic pathogen Enterococcus faecalis improved their pathogenic behavior in Galleria mellonella larvae [54]

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Radiotherapy affects regional vascular structures, leading to increased vascular fragility in the periorbital area