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They include CAMP-response element binding protein (CREB), SP1 transcription factor (SP1), transcription factor AP-2 (AP2), proliferator-activated receptor alpha (PPAR), all activating GPX4 expression, while Krppel-like transcription factor 2 (KLF2) and CAMP-response element modulator (CREM), both repress its protein expression [7]

PMID: 39293861 Phytother ResTanshinone IIA relieves arthritis by inhibiting autophagy of fibroblast-like synoviocytes via matrix metalloproteinase9/receptor for advanced glycation end product/toll-like receptor 9 signal axis in mice with collagen-induced arthritis

From the included human studies, five studies were observational and only three studies were clinical trials

doi: 10.1007/s00213-021-05958-w