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Using this system, compound W478 was identified as a previously unobserved SHMT2 inhibitor, which is distinguished from previously reported inhibitors of SHMT2, such as antifolate analogues and pyrazolopyran derivatives, by virtue of its unique chemical structure

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Valorization of PE plastic waste into lipid cells through tandem catalytic pyrolysis and biological conversion

35, 36 Mice were weighed twice weekly to assess toxicity and killed when tumors reached 1500 mm 3 or they experienced any severe morbidity (that is, body weight 2, (b) a significant difference ( P 60% were considered to have low activity