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However, emerging evidence suggests that exosomes possess tissue tropism in the context of mucus-rich environments, which may help to mediate tissue targeting despite mucus barriers 214

Failure to do so may convert L-tyrosine into a drug with side effects

Though M1 and M2 represent the two extreme phenotype characteristics of macrophage activation stages regulated by redox metabolism, tissue-resident macrophages comprise a distinct subset and hold tissue-specific functions dependent on oxygen and nutrient supply, which can certainly influence redox status and metabolism (112)

Each type of MT genes displays a distinct spatial and temporal expression pattern (Cobbett and Goldsbrough, 2011)