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Cell Mol Life Sci 74 , 31853204, (2017)

Localized Surface Plasmon Resonance Sensors

Glutathione oxidized by allicin forms S-allylmercaptoglutathione (GSSA) Cysteine oxidized by allicin forms S-allylmercaptocysteine (CSSA) GSSA and CSSA were found to increase overall cellular glutathione levels by a measure of 15 times the amount of allicin itself, a finding that suggests that allicins reactivity with cellular thiols is one of the main drivers of its antioxidant boosting activity

Severity of presentation depends on: Percentage of MetHb Rate of increase in MetHb levels The intrinsic ability of the patient to prevent or reduce MetHb The patients underlying functional status Symptoms depend on the level of MHb and its rapidity of formation, and include: 12 Dyspnea Anxiety Headache Fatigue Weakness CNS depression Dizziness Cyanosis Seizures Signs include: Cyanosis: As little as 1.5 g methemoglobin in 100 ml blood (1.5 g%) can produce clinically recognizable cyanosis