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Spermine-induced ferroptosis is mediated by the metabolite acrolein Spermine is biochemically converted to another polyamine called spermidine and subsequently to the polyamine putrescine 41

In HEK293T cells, UBE2O overexpression leads to a dose-dependent reduction of endogenous BMAL1, while its knockdown increases BMAL1 protein levels ( UBE2O overexpression attenuates BMAL1-driven transcription and dampens downstream circadian outputs, while its silencing increases PER2 rhythm amplitude, confirming its role in maintaining clock dynamics (Maffeo and Cilloni, 2024)

and piperideine-6-carboxylate (P6C), a diastereoisomer derivative, are suitable biomarkers for pyridoxine-dependent epilepsy ( Table 3

This mutation reduces astrocytic Cl levels and trigger apoptosis 323