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Pharmacol Res Perspe 2021;9:e00835

Liver glutathione declines 35-50% in aged animals [7] , while brain glutathione drops by at least 50% over adult aging [8]

Gibson JB, Carson NA, Neill DW (1964) Pathological Findings in Homocystinuria

The role of apoE/TREM2 signaling in regulating microglial phagocytosis was confirmed in multiple studies involving AD mouse models and postmortem human brains [140, 141]