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Besides, they found that patients responding to PD-1 treatment have lower levels of MOESIN lactylation than nonresponders, providing a novel idea of targeting Treg cells via anti-lactate approaches in enhancing tumor immunotherapy (Fig

Next to the enzymatic decomposition of ROS by catalase, ascorbate peroxidase (APX) or other enzymes in the glutathione-ascorbate cycle, the non-enzymatic way by low molecular weight antioxidants, like glutathione (GSH) and ascorbate has crucial role to balance cellular redox changes (Foyer and Noctor, 2013)